Figure 1From: EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cellsGlucose, insulin, and EGF induce survivin protein expression. MIN6 and INS-1 cells were serum-deprived for 2 to 4 hours (A and B) or overnight (C and D) then glucose, insulin, or EGF (50 ng/ml) were added at the indicated concentrations and times. (A) Survivin protein levels in response to glucose in MIN6 cells. (B) Survivin protein levels in response to insulin in MIN6 cells. (C) Survivin protein levels in response to EGF in INS-1 cells. (D) Survivin protein levels in response to EGF in MIN6 cells.Back to article page