Figure 4
From: The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements
Model of MBNL1 binding RNA. Space-filling and stick model of MBNL1 ZnFs3/4 with CGCUGU RNA (PDB 3D2S) and MBNL1 ZnFs1/2 (PDB 3D2N). Tan = ZnF1, Magenta = ZnF2, Yellow = ZnF3, Red = ZnF4. Nucleotides making base specific contacts to ZnF3 are in white. These nucleotides come from two separate RNAs within the crystallized structure. Light blue is a cytidine from the ZnFs3/4 structure that has been modeled into the proposed cytidine binding pocket (green) of ZnF1, based upon sequence alignment with ZnFs3/4. The amino acid linker between ZnFs1/2 and ZnFs3/4 is modeled as a black line.