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Table 1 Comparison of a spectrum of stress genes (hsp family) affected by Lipofectamine 2000 versus heat shock in B16F10 cells

From: Liposome-based DNA carriers may induce cellular stress response and change gene expression pattern in transfected cells

Gene

LA

HS

Hspa1b

+

+

Hsph1 (hsp105)

+

+

Hspa8 (hsc70)

+

+

Dnajb4

+

+

Hspa4 (hsp70RY)

-

 

Hspa1a (hsp70.3)

 

+

Hspb1 (hsp27)

 

+

Hspa4l (94kDa osmotic stress protein)

 

+

Hspe1 (hsp10)

 

+

Hsph1 (hsp110)

 

+

  1. LA - Lipofectamine 2000, HS - heat shock, "+" - increased expression compared to control, untreated cells, "-" - decreased expression, blank - no change.