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Table 1 A comparison of oligonucleotide-based strategies for polyQ diseases based on the desired properties of the reagents

From: An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases

PROPERTIES OF REAGENT

STRATEGIES

target specificity

allele selectivity

universality

stability in cells

delivery in shRNA

Specific silencing by RNAi

uncertain

no

uncertain

uncertain

yes

Replacement strategy

uncertain

uncertain

uncertain

uncertain

yes

SNP targeting

uncertain

yes

no

uncertain

yes

Repeat targeting by siRNA

no

no

yes

uncertain

yes

Repeat targeting by miRNA

uncertain

yes

yes

uncertain

yes

Repeat targeting by ASO

uncertain

yes

yes

yes

no