From: An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases
PROPERTIES OF REAGENT | |||||
---|---|---|---|---|---|
STRATEGIES | target specificity | allele selectivity | universality | stability in cells | delivery in shRNA |
Specific silencing by RNAi | uncertain | no | uncertain | uncertain | yes |
Replacement strategy | uncertain | uncertain | uncertain | uncertain | yes |
SNP targeting | uncertain | yes | no | uncertain | yes |
Repeat targeting by siRNA | no | no | yes | uncertain | yes |
Repeat targeting by miRNA | uncertain | yes | yes | uncertain | yes |
Repeat targeting by ASO | uncertain | yes | yes | yes | no |