Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

Fietz, D.; Markmann, M.; Lang, D.; Konrad, L.; Geyer, J.; Kliesch, S.; Chakraborty, T.; Hossain, H.; Bergmann, M.

doi:10.1186/s12867-015-0051-7

BMC Molecular Biology

Table 1 Overview of ten highest ranked up- and down-regulated genes

From: Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

Regulation	Identifier	Symbol	EntrezID	FDR	FC	Gene name	Comment
Down	Idx_R307_C32	Cybrd1	295,669	0.001	−107,712	Cytochrome b reductase 1	Expression of the ferric reductase is regulated by intracellular iron concentration and other facilitators of iron absorption, indicating that it responds to iron demand
Down	Idx_R293_C42	Tmsbl1	286,978	0.003	−71,936	Thymosin beta-like protein 1	Actin cytoskeleton organization
Down	Idx_R29_C52	Nnat	94,270	0.001	−50,214	Neuronatin	The effects of Nnat on inflammatory pathways in vitro and in vivo suggest a pathophysiological role of this new gene in diabetic vascular diseases
Down	Idx_R245_C71	Fam46a	300,870	0.006	−42,921	Family with sequence similarity 46, member A
Down	Idx_R259_C49	Ctsz	252,929	0.003	−39,163	Cathepsin Z	Accounts for the lysosome’s capacity to digest polyQ sequences. Cathepsins L and Z are important in defending against the accumulation and toxicity of polyQ proteins
Down	Idx_R322_C43	Slc24a3	85,267	0.003	−38,220	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Down	Idx_R196_C66	Nudt7	361,413	0.004	−36,487	Nudix (nucleoside diphosphate linked moiety X)-type motif 7
Down	Idx_R200_C18	Marveld1	309,375	0.001	−34,855	MARVEL domain containing 1
Down	Idx_R240_C21	Tpp1	83,534	0.001	−32,489	Tripeptidyl peptidase I
Down	Idx_R245_C74	Tpp1	83,534	0.001	−31,626	Tripeptidyl peptidase I
Down	Idx_R47_C36	Bhlhb9	317,407	0.001	−30,042	Basic helix-loop-helix domain containing, class B, 9
Up	Idx_R117_C7	Irf7	293,624	0.003	5540	Interferon regulatory factor 7	The crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from pathogen recognition receptors (PRRs) that recognize pathogenic nucleic acids
Up	Idx_R14_C99	Apol9a	503,164	0.003	5611	Apolipoprotein L 9a
Up	Idx_R252_C110	Usp18	312,688	0.003	5976	Ubiquitin specific peptidase 18
Up	Idx_R317_C53	Usp18	312,688	0.003	6264	Ubiquitin specific peptidase 18
Up	Idx_R74_C32	Wfdc18	171,059	0.004	6291	WAP four-disulfide core domain 18
Up	Idx_R53_C102	Ripk4	304,053	0.001	6479	Receptor-interacting serine-threonine kinase 4
Up	Idx_R278_C80	Ccl4	116,637	0.006	7177	Chemokine (C–C motif) ligand 4
Up	Idx_R188_C91	Oas1b	246,268	0.003	7827	2–5 oligoadenylate synthetase 1B
Up	Idx_R192_C96	Ffar4	294,075	0.004	9720	Free fatty acid receptor 4
Up	Idx_R299_C11	Il33	361,749	0.002	9759	Interleukin 33	IL-33 is a dual function protein that may function as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties
Up	Idx_R66_C107	Il33	361,749	0.001	10,690	Interleukin 33
Up	Idx_R102_C39	Mx1	24,575	0.004	12,708	Myxovirus (influenza virus) resistance 1	The human myxovirus resistance protein 1 is a key mediator of the interferon-induced antiviral response against a wide range of viruses. MxA may form oligomeric rings around tubular nucleocapsid structures. As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles

Back to article page

ISSN: 1471-2199

Contact us

General enquiries: ORSupport@springernature.com