Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

Fietz, D.; Markmann, M.; Lang, D.; Konrad, L.; Geyer, J.; Kliesch, S.; Chakraborty, T.; Hossain, H.; Bergmann, M.

doi:10.1186/s12867-015-0051-7

BMC Molecular Biology

Table 2 Overview of functional gene ontology categories according to their pattern of significantly regulated genes

From: Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

Group	Cluster#	Cluster of GO categories	Score		Symbols
Cell development/cell contact [106]	1	Biological adhesion (4) [25]	2.27	Up	Vnn1, Amigo2, Bcam, Cdh2, Ceacam1, Col12a1, Col14a1, Col16a1, Dsg2, Gpc1, Mcam, Omd, Sned1, Col18a1, Ctgf, Gpr56, Ncam1, Igfbp7
	1	Biological adhesion (4) [25]	2.27	Down	Itgb8, F5, Pcdh1, Pcdh18, Plcxd2, Ptprm, Ctgf
	3	Axonogenesis (13) [36]	1.89	Up	Aldh1a2, Apbb1, Apoe, Boc, Cd24, Cdkn1c, Chn2, Col18a1, Col18a1, Cxcl12, Efna2, Efnb1, Fgfr2, Gli2, Gpc2, H19, Hoxc10, Krt19, Lpar3, Nnat, Nrep, Obsl1, Pmp22, Ppp1r9a, Prickle2, Sdc2, Sema4f, Shroom3, Sox5, Uchl1
	3	Axonogenesis (13) [36]	1.89	Down	Ptprm, Epha7, Dpysl3, Mtss1, Nes, Sgk1
	4	Retinoid metabolic process (5) [8]	1.75	Up	Akr7a3, Aldh1a2, As3mt, Ldhb, Rarres2, Rbp1
	4	Retinoid metabolic process (5) [8]	1.75	Down	Crabp2, Rbp2
	7	Epithelium development (15) [50]	1.47	Up	Acp5, Adamts1, Adck3, Aldh1a2, Celsr1, Col18a1, Col1a1, Col4a1, Cxcl12, Disp1, Efna2, Efnb1, Fbn1, Fgfr2, Foxe1, Foxl2, Gli2, H19, Hmx2, Hoxc10, Irf6, Kazn, Mgp, Mn1, Mycn, Pgf, Plce1, Serpinf1, Sfrp2, Shroom3, Sox5, Spry1, Srgn, Tbx18, Tbx4, Tek, Tgfb1i1, Tgm2, Upk1b
	7	Epithelium development (15) [50]	1.47	Down	Ctgf, Crabp2, Fst, Ptger2, Rsad2, Cdx2, Hoxb6, Krt14, Ptgs2, Foxp2, Myc
H [36]	2	Response to steroid hormone stimulus (10) [36]	1.90	Up	Acp5, Adamts1, Adck3, Aldh1a2, Apoe, Boc, Cd24, Celsr1, Col1a1, Cxcl12, Disp1, Efna2, Efnb1, Fgfr2, Gli2, Gpr56, H19, Igfbp7, Krt19, Lpar3, Mgp, Ncam1, Nnat, Pgf, Plce1, Sdc2, Serpinf1, Sfrp2, Tek, Tgfb1i1, Tgm2
H [36]	2	Response to steroid hormone stimulus (10) [36]	1.90	Down	Foxp2, Myc, Nes, Ptgs2, Sgk1
Immune response [55]	5	Innate immune response (4) [34]	1.69	Up	Acp5, Adck3, Afap1l2, Apbb1, C2, Cd24, Cxcl12, Cyp4f6, Il27ra, Masp1, Ptpn6, RT1-DMb, Tf, Tgm2, Tinagl1, Tlr2, Vnn1, Zfr2
	5	Innate immune response (4) [34]	1.69	Down	A2 m, C3ar1, Ccl2, Ccl4, Ereg, F2rl1, Gch1, Il1rl1, Irf7, Irgm, Nppb, Oas1b, Oasl2, Prg4, Ptgs2, Rsad2
	8	Cell surface receptor linked signal transduction (3) [25]	1.35	Up	Adamts1, Adck3, Apoe, Boc, Cd24, Celsr1, Cxcl12, Disp1, Efna2, Efnb1, Fgfr2, Gli2, Gpr56, Lpar3, Ncam1, Plce1, Sfrp2, Tek, Tgfb1i1, Tgm2
	8	Cell surface receptor linked signal transduction (3) [25]	1.35	Down	Ctgf, Epha7, Fst, Itgb8, Ptger2
N [12]	6	Nucleotide catabolic process (7) [12]	1.47	Up	Akr7a3, Ampd3, Gucy1b3, Nt5e, Nudt7, Pde4a, Pde4b, Prodh
N [12]	6	Nucleotide catabolic process (7) [12]	1.47	Down	Gch1, Nppb, Ppat, Upp1

Numbers in normal brackets denote the number of grouped GO categories. Absolute numbers of regulated genes per main group are given in squared brackets, examples of regulated genes are shown for up- and down-regulated genes
H hormone stimulus, N Nucleotide Catabolic Process

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