Fig. 3
From: Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer
Sequence alignment of the mouse and human enhancer regions E3 and E4 located 3′ of the c-Myc gene. Consensus STAT5 binding sites (TTCNNNGAA) that are conserved between mouse and human sequences are designated as white boxes. Non-consensus STAT5 binding sites (usually TTCNNNNAA or TTNNNNGAA) are underlined [46]. E3 and E4 contain each one consensus and a cluster of 8–9 non-consensus putative STAT5 binding motifs that are well-conserved in both mouse and human genomes at the same position. Such pattern of conserved motifs was absent from E1, E2 and E5 elements (not shown)