Fig. 2
From: Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure
Analysis of differentiation markers in Dgcr8–Pax8Cre knockout thyroid glands. Immunohistochemistry of thyroid differentiation markers show a strong reduction of Tg expression. Pax8, Nkx2.1 and Foxe1 expression levels are unaffected in the residual follicular cells, as well as the expression of their target Nis. No alteration in calcitonin cells was observed. (40× magnification for Tg, Pax8, calcitonin, Nkx2.1 and Foxe1 bar 50 μm; 100× magnification for Nis, bar 10 µm, age of the mice 4–8 weeks)