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Fig. 7 | BMC Molecular Biology

Fig. 7

From: Properties of STAT1 and IRF1 enhancers and the influence of SNPs

Fig. 7

STAT1 and IRF1 binding correlates with binding motifs. a Percent distribution of isolated STAT1 or IRF1 or dual STAT1 + IRF1 binding at proximal (≤5 kb) or remote (>5 kb) sites of Known gene promoters. b TF binding sites were classified into 6 subclasses, then mapped motifs using CisGenome’s “Known Motif Mapping” program (see “Methods” section for details). Sets of equal numbers of randomly generated “peaks” were used to define the background occurrence of STAT1 and IRF1 motifs. Asterisk indicates significant difference between true and random peaks (p < 0.00005, two-sided probability test in R). c Ratio of STAT1/IRF1 motifs at different categories of peaks

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