Fig. 8

STAT/IRF1 recruitment at es-indISGs vs res-ISGs. a Map of isolated and dual STAT1 and IRF1 binding ± 100 kb of the TSS of es-indISGs (top) and resISGs (bottom), after removing CIITA targets, in HeLa cells treated for 6 h with IFNγ. Red arrow indicated TSS and direction of transcription. Genes are ranked according to fold induction, indicated in brackets. b Histograms show the percentage of es-indISGs or resISGs with proximal (≤5 kb) or distal (>5 kb) binding of STAT1 and/or IRF1. Asterisk p < 0.05, Fisher exact test. c Average number of TF binding events at proximal and remote sites at resISGs or es-indISGs. Error bar: SEM; Asterisk p < 0.05, ANOVA followed by Fisher test