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Table 2 The top 10 enriched biological process, cell component and molecular function GO terms for DEGs, which were sorted respectively by p-value in ascending

From: MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells

Category

Term

Count

p-value

Fold enrichment

GOTERM_BP_DIRECT

GO:0007565 ~ female pregnancy

13

2.86E−04

3.534242

GOTERM_BP_DIRECT

GO:0007267 ~ cell–cell signaling

24

3.61E−04

2.286233

GOTERM_BP_DIRECT

GO:0008152 ~ metabolic process

18

5.93E−04

2.592425

GOTERM_BP_DIRECT

GO:0007165 ~ signal transduction

69

0.002168

1.438003

GOTERM_BP_DIRECT

GO:0001525 ~ angiogenesis

20

0.002302

2.170042

GOTERM_BP_DIRECT

GO:0008277 ~ regulation of G-protein coupled receptor protein signaling pathway

7

0.00493

4.342866

GOTERM_BP_DIRECT

GO:0030168 ~ platelet activation

12

0.007956

2.524796

GOTERM_BP_DIRECT

GO:0006687 ~ glycosphingolipid metabolic process

7

0.009997

3.763817

GOTERM_BP_DIRECT

GO:0071526 ~ semaphorin–plexin signaling pathway

6

0.010737

4.399266

GOTERM_BP_DIRECT

GO:0016266 ~ O-glycan processing

8

0.011451

3.226129

GOTERM_CC_DIRECT

GO:0005615 ~ extracellular space

109

1.54E−11

1.95324

GOTERM_CC_DIRECT

GO:0005576 ~ extracellular region

123

2.57E−11

1.844064

GOTERM_CC_DIRECT

GO:0005886 ~ plasma membrane

214

1.33E−04

1.253453

GOTERM_CC_DIRECT

GO:0005578 ~ proteinaceous extracellular matrix

25

3.33E−04

2.251656

GOTERM_CC_DIRECT

GO:0016021 ~ integral component of membrane

251

0.001739

1.17346

GOTERM_CC_DIRECT

GO:0005581 ~ collagen trimer

11

0.004686

2.886035

GOTERM_CC_DIRECT

GO:0009986 ~ cell surface

36

0.00631

1.603245

GOTERM_CC_DIRECT

GO:0005887 ~ integral component of plasma membrane

76

0.015603

1.296444

GOTERM_CC_DIRECT

GO:0002177 ~ manchette

3

0.015728

14.48265

GOTERM_CC_DIRECT

GO:0005884 ~ actin filament

8

0.017555

2.9708

GOTERM_MF_DIRECT

GO:0046934 ~ phosphatidylinositol-4,5-bisphosphate 3-kinase activity

10

8.46E−04

3.963234

GOTERM_MF_DIRECT

GO:0005125 ~ cytokine activity

18

8.47E−04

2.513051

GOTERM_MF_DIRECT

GO:0004867 ~ serine-type endopeptidase inhibitor activity

12

0.001915

3.039842

GOTERM_MF_DIRECT

GO:0008083 ~ growth factor activity

16

0.002531

2.426869

GOTERM_MF_DIRECT

GO:0008201 ~ heparin binding

15

0.005735

2.30363

GOTERM_MF_DIRECT

GO:0008401 ~ retinoic acid 4-hydroxylase activity

3

0.009368

18.42904

GOTERM_MF_DIRECT

GO:0005102 ~ receptor binding

25

0.009977

1.74023

GOTERM_MF_DIRECT

GO:0005509 ~ calcium ion binding

42

0.017368

1.439367

GOTERM_MF_DIRECT

GO:0032395 ~ MHC class II receptor activity

4

0.021097

6.552547

GOTERM_MF_DIRECT

GO:0001665 ~ alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

3

0.022182

12.28603

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BMC Molecular Biology

ISSN: 1471-2199

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