Fig. 1
From: The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression
Exogenous Aβ1-42 promotes Aβ production by increasing BACE1-AS expression in SH-SY5Y cells. After treating SH-SY5Y cells with Aβ1-42, the expression of BACEl-AS and BACEl were significantly elevated (*P < 0.05). After the pretreatment with BACE1-AS siRNA for 24 h followed by treatment with Aβ1-42, the expression of BACEl-AS and BACE1 mRNA significantly decreased (*P < 0.05) (a). After treating SH-SY5Y cells with Aβ1-42 , the expression of BACEl and C1F protein (b, c), and also the concentration of Aβ1-40 (d) in extracellular fluid were significantly elevated (*P < 0.05). After the pretreatment with BACEl-AS siRNA for 24 h followed by treatment with Aβ1-42 for 2 h, the expression of BACEl and CTF protein (b, c), and also the concentration of Aβ1-40 (d) significantly decreased (*P < 0.05)